Decoding Cellular Longevity Through Science
Discover how PCC1 extends lifespan by targeting cellular senescence. Research from 199 Biotechnologies reveals the longevity blueprint through advanced senolytic compounds.
Selectively eliminates senescent cells through apoptosis. PCC1's senolytic properties make it a powerful life extension compound in the longevity blueprint.
Beyond senolytic activity, PCC1 exhibits senomorphic properties, modifying SASP to reduce inflammation and support healthy aging pathways.
Research by 199 Biotechnologies shows PCC1 extended median lifespan by 64.2% in aged models, demonstrating powerful longevity supplement potential.
Cellular senescence drives aging. Senolytic compounds like Procyanidin C1 represent the future of life extension science.
Senescent cells accumulate with age, secreting inflammatory factors that damage surrounding tissues. This cellular senescence accelerates aging and age-related diseases.
Procyanidin C1 acts as a targeted senolytic, clearing damaged cells while preserving healthy ones. This selective action is key to effective life extension strategies.
Stay informed about senolytic research, life extension studies, and longevity supplement developments from 199 Biotechnologies.
Groundbreaking research reveals how Procyanidin C1 activates the brain's master defense system to protect neurons from glutamate-induced death—a discovery that could transform our approach to treating stroke, Alzheimer's, and Parkinson's disease.
Explore how procyanidin C1 transforms gut health by orchestrating beneficial changes in the microbiome, strengthening intestinal barriers, and reducing inflammation through sophisticated biological mechanisms.
Single-cell analysis revealing PCC1's broad geroprotective effects on hematopoietic and immune systems through senolytic and senomorphic mechanisms.
Aging-related skin fibrosis (SF) is a complex condition with limited treatment options. Procyanidin C1 (PCC1), a natural polyphenolic compound with demonstrated senolytic activity, has emerged as a potential therapeutic agent for fibrotic disorders throu …
Latest research demonstrating PCC1's senolytic role in alleviating renal fibrosis by specifically targeting senescent renal tubular epithelial cells.
In the intricate world of molecular biology, where the smallest interactions can determine the fate of entire cells, researchers have uncovered a fascinating story about how procyanidin C1 positions itself at the critical interfaces of our cellular membranes—a discovery that revolutionizes our understanding of this remarkable senolytic compound.
Groundbreaking research reveals how Procyanidin C1 orchestrates profound rejuvenation of hematopoietic and immune systems through dual senolytic and senomorphic mechanisms at the single-cell level.
Demonstrates PCC1's protective effects against intervertebral disc degeneration through SIRT3/FOXO3-mediated mitochondrial dynamics regulation.
Recent research illuminates how PCC1 orchestrates a sophisticated molecular symphony that reverses aging-related skin fibrosis through precise modulation of the EGFR/TGFβ/SMAD signaling axis.
Central South University research unveils how PCC1 operates as a precision-guided therapeutic missile against senescent cells orchestrating kidney fibrosis through the ANGPTL4/NOX4 pathway.
Groundbreaking research demonstrates PCC1's protective effects against intervertebral disc degeneration through SIRT3/FOXO3-mediated mitochondrial dynamics regulation in acidic environments.
Shows PCC1's ability to improve lung fibrosis by promoting apoptosis in senescent myofibroblasts, providing therapeutic approach for pulmonary fibrosis treatment.
FASEB Journal research reveals PCC1's remarkable ability to selectively eliminate senescent myofibroblasts through the PUMA-BCL-XL-BAX pathway, offering new hope for pulmonary fibrosis treatment.
Demonstrates PCC1's senolytic and senomorphic properties in ameliorating age-related retinal impairment through comprehensive single-cell RNA sequencing analysis of retinal landscape changes.
PNAS research reveals PCC1's remarkable ability to rejuvenate aging retinas through both senolytic and senomorphic mechanisms, offering new hope for age-related vision loss.
Recent research unveils PCC1's protective mechanisms against ferroptosis through Nrf2/HO-1 pathway activation, offering new therapeutic approaches for inflammatory and neurodegenerative diseases.
Demonstrates procyanidin's protective effects against ferroptosis and inflammation through Nrf2/HO-1 pathway modulation.
Shows procyanidin C1's anti-colon cancer effects through modulation of miR-501-3p/HIGD1A axis, inhibiting tumor growth and metastasis.
Comprehensive review of procyanidin C1 and other procyanidins' effects on gut health and microbiota interactions.
Optimizes extraction of procyanidins including PCC1 from coffee pulp using novel hybrid microwave-ultrasound extraction method.
Get the latest senolytic research, life extension insights, and longevity blueprint updates from 199 Biotechnologies.
Led by Boris Djordjevic and the 199 Longevity Clinic team