Unlocking the Power of Procyanidin C1
Exploring the senolytic complex that extends lifespan and combats cellular aging.
The Science of PCC1
Procyanidin C1 is a trimeric procyanidin with remarkable senolytic and senomorphic properties.
Senolytic Activity
Selectively eliminates senescent "zombie" cells while sparing healthy cells, reducing harmful inflammatory compounds.
Senomorphic Effects
Modifies senescent cell behavior to reduce harmful inflammatory signals (SASP), decreasing negative impact on tissues.
Lifespan Extension
Research shows PCC1 extended median post-treatment lifespan by 64.2% in aged mice, equivalent to humans 75-90 years old.
Mechanism of Action
PCC1 works through several biological pathways to support cellular health:
- •Inhibition of PI3K/AKT pathway in senescent cells
- •Reduction of inflammatory compounds (IL-6, IL-8, TGF-β)
- •Antioxidant activity combating oxidative stress
- •Improved physical function and cardiovascular parameters
Recent Research
The latest studies exploring Procyanidin C1's effects on aging and age-related conditions.
PCC1 Rejuvenates Retinal Function in Aging Mice
Recent PNAS study shows PCC1 can rejuvenate retinal function by targeting senescent cells in the retina.
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